Design and implement experiments to screen for drug candidates, and to address mechanisms-of-action of therapeutic molecules. Perform complex cell-based functional experiments independently. Act as a subject matter expert (SME) for drug discovery in the Cell therapy pillar.
location: Cambridge, Massachusetts
job type: Contract
salary: $40 - 48 per hour
work hours: 9 to 5
education: Bachelors
responsibilities:
- Design and implement experiments to screen for drug candidates, and to address mechanisms-of-action of therapeutic molecules. Perform complex cell-based functional experiments independently. Act as a subject matter expert (SME) for drug discovery in the Cell therapy pillar.
- Provide broad assay development support for early stage drug discovery projects in disease
areas of the Cell therapy and Immuno-Oncology/Immuno Therapy - Design, execute and validate a variety of assays to understand mechanism of action and characterize cell therapy new modalities (e.g., CAR-T, CAR-NK)
- Collaborate with automation engineers to identify suitable approaches to utilize laboratory automation for the execution of variable cell based assays.
- CAR T/NK generation (transduction and expansion) and functional evaluation of CAR expression, phenotyping, cytokine detection and killing potency in vitro.
- Spend ~ 85% of time in laboratory to maintain and implement cell based assay platform and perform experiments
- Interface with project teams to meet timelines for project progression
- Present research findings clearly and effectively at internal and external meetings
- Troubleshoot complex problems in creative and effective ways
qualifications:
Required:
- PhD degree in cell immunology, protein/antibody science.
- If no PhD, would accept a Master degree and 2+ years of related experience.
- If no PhD or Masters, would accept a Bachelor's degree with +6 years relevant experience.
- Strong knowledge of T/NK cell biology, immuno-oncology, and cell therapy
- Tissue culture including application of aseptic techniques for media compounding, passaging,
- Maintenance and cryopreservation of cell cultures.
- Experience with immune cell (T/NK cells) isolation, culture and engineering.
- Proficiency in immune cell phenotyping (surface/intracellular), cytokine detection (multi-color flow
- Cytometry, Luminex, MSD), cytotoxicity assay and High content imaging (Opera Phenix) or other functional assays.
- Proficient in data generation (prism, excel), presentation and troubleshooting.
- Knowledge and experienced in cell biology and antibody characterization
- Skilled in data analysis, interpretation, and data reporting
- Hands-on cell-based functional assay experience
- Experience with viral delivery methods is a plus.
- Experience in troubleshooting, assay optimization and data quality control is a plus
skills: Assay Development, Assay Method, Assay Verification, In Vitro, Flow Cytometry
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.
At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact HRsupport@randstadusa.com.
Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including health, an incentive and recognition program, and 401K contribution (all benefits are based on eligibility).
This posting is open for thirty (30) days.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
