The Drug Metabolism and Disposition group in QTAS has an open position for a Senior /Research Associate Scientist to perform drug metabolism/metabolite identification studies supporting a series of small molecule drug discovery projects.
The selected candidate will be responsible for designing and conducting in vitro metID studies, processing the data, and interpreting MS/MS results. It is a fully drug metabolism laboratory-based role.
It would be advantageous for the candidate to have practical hands-on experience performing in vitro and in vivo biotransformation studies, liquid chromatography, mass spectrometry, structure elucidation/identification, fit-for purpose analytical method development including cross-species metabolite profiling.
location: Cambridge, Massachusetts
job type: Contract
salary: $45.00 - 50.76 per hour
work hours: 9 to 5
education: Bachelors
responsibilities:
This role is fully lab based. Responsibilities include but not limited to:
- Perform routine soft-spot identification studies and investigational vitro studies to address specific DMPK questions in drug discovery from lead optimization to candidate selection processes
- Develop a series of analytical methods using a mass spectrometer (LC-MS/MS) to separate and detect small molecules
- Conduct in-depth analysis of Thermo Exploris 240/ QE LCMS/MS data by using Chemdraw, MassFrontier, Compound Discovere, Webmetabase platform
- Assume responsibility for maintaining laboratory equipment and maintain clear, detailed, and up-to-date experimental records
- Prepare and deliver scientific presentations and reports to communicate research results within and outside the DMPK department
- Conduct other duties as assigned
- Maximize the experience at one of the best places to work environment at Company, with opportunities to network and learn from other professionals in adjacent fields
qualifications:
Required Qualifications:
- Bachelor's (Chemistry/Analytical Chemistry/Biological Sciences/Biochemistry)
- 5 years drug metabolism/met ID lab experience (mass spectrometer)
- Hands on Lab experiences performing metabolic stability, CYP inhibition, and metabolite ID studies in liver subcellular fractions and hepatocytes
- Experience preparing and analyzing samples from in vivo biological matrices using a mass spectrometer (LC-MS/MS)
- Master's (Organic Chemistry/Analytical Chemistry/Biochemistry) with 3 years experience
- In vivo biological matrices analysis (LC-MS/MS) experience
- LC-MS/MS (Thermo Exploris 240/QE) proficiency
- Liver subcellular fractions/hepatocytes experience
- Independent experiment planning/execution
skills: Analytical Chemistry, Chemistry, In Vivo
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.
At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact HRsupport@randstadusa.com.
Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including health, an incentive and recognition program, and 401K contribution (all benefits are based on eligibility).
This posting is open for thirty (30) days.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
